Multiple Sclerosis Health Resource Utilization Survey

The Multiple Sclerosis Health Resource Utilization Survey (MS-HRS) is a multilingual, reliable, valid and easy to administer questionnaire providing a holistic cross-sectional and longitudinal assessment of resource utilization in people with multiple sclerosis.

An expert group consisting of neurologists, healthcare administrators, psychologists and MS nurses at the Multiple Sclerosis Centre, University Hospital Dresden developed the item pool in German between 2011 and 2014. The first version of the MS-HRS was created as addition to register-like non-interventional studies that were emerging at the time. After incorporating the feedback from patients, nurses and physicians, a second version was built in 2016 that aimed to be more time-efficient. The adaptive version of the MS-HRS in its German and translated English version is the result of the third round of development.


Der Multiple Sclerosis Health Resource Utilization Survey. Ness NH, Schriefer D, Haase R, Ziemssen T. Fortschr Neurol Psychiatr. March 2021. DOI: 10.1055/a-1471-3636

Gender disparities in health resource utilization in patients with relapsing–remitting multiple sclerosis: a prospective longitudinal real-world study with more than 2000 patients. Schriefer D, Ness NH, Haase R, Ziemssen T. Therapeutic Advances in Neurological Disorders. January 2020. DOI: 10.1177/1756286420960274

Relapses in multiple sclerosis reported by patients versus physicians - Insights from a large observational study. Schriefer D, Haase R, Ettle B, Ziemssen T. Eur. J. Neurol., 27: 2531-2538. DOI: 10.1111/ene.14432

The Multiple Sclerosis Health Resource Utilization Survey (MS-HRS): Development and Validation Study. Ness NH, Haase R, Kern R, Schriefer D, Ettle B, Cornelissen C, Akguen K, Ziemssen T. J Med Internet Res 2020;22(3):e17921. DOI: 10.2196/17921

Real-World Evidence on the Societal Economic Relapse Costs in Patients with Multiple Sclerosis. Ness NH, Schriefer D, Haase R, Ettle B, Ziemssen T. PharmacoEconomics (2020). DOI: 10.1007/s40273-020-00917-3c

Differentiating societal costs of disability worsening in multiple sclerosis. Ness NH, Schriefer D, Haase R, Ettle B, Cornelissen C, Ziemssen T. 2019. J Neurol. 2019 Dec 17. DOI: 10.1007/s00415-019-09676-4.

Development of the adaptive, bilingual Multiple Sclerosis Health Resource Survey (MS-HRS). Haase R, Kern R, Akgün A., Wunderlich M, Dominik M, Ziemssen T. 2018. 34th Congress of the European Committee for Treatment and Research in Multiple Sclerosis, Berlin.


Creative Commons Lizenzvertrag Multiple Sclerosis Health Resource Utilization Survey by Tjalf Ziemssen is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License.

If the MS-HRS is used in a study with a commercial sponsor, a Commercial User agreement must be signed. A Commercial User Agreement is required for each study and a fee is charged based on the number of patients in the study. For further information and permissions not being covered under CC-BY-NC-CD, please contact Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!.