I refer, of course, to the splendid work “Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active MS lesions”, a scientific dossier that reads as though the authors had been peering over my shoulder while I inspected the MS-affected brain through my magnifying lens.

Fifty years of monoclonal antibodies. And of course, it’s a criminal case ...

Before anyone says “MS?”, the nervous system is already whispering ...

Metabolism. When you don’t know whom to suspect – it’s almost always metabolism. ⚙️🍽️

Vaccines aren’t extras, they work undercover. In oncology, they boost the good – waking the neighborhood so therapy can aim true. In neurology, they dampen the bad – catching sparks before they ignite.

In front of me is a fresh piece of evidence: a paper in Science Translational Medicine 📄🧪 about a new crime-scene method in MS—SV2A-PET with [18F]UCB-H. A radioactive mini-tracer that attaches to synapses and makes them visible on PET 🔦🧠. A flashlight for the contact points between nerve cells 🔌.